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Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer 期刊论文

编号：

9EBA937CA58A69684F8D5E9C0E038C23
作者：

Zhou, Xuantong#^[1]You, Min#^[2,3]Wang, Fuhui^[4];Wang, Zhenzhen^[2,3];Gao, Xingfa^[2,3,5];Jing, Chao(井超)^[6]Liu, Jiaming^[2,3,5];Guo, Mengyu^[2,3,5];Li, Jiayang^[2,3,7,8];Luo, Aiping*^[1,7]Liu, Huibiao*^[4,7]Liu, Zhihua*^[1,7]Chen, Chunying*^[2,3,5,7,8]
语种：

英文
期刊：

ADVANCED MATERIALS ISSN：0935-9648 2021 年 33 卷 24 期 ; JUN
收录：
关键词：

GDY&amp #8211 CeO (2) nanozymes human sophageal squamous cell carcinoma hypoxia alleviation miR&amp #8208 181a&amp 2&amp 3p radiosensitizers
摘要：

Radioresistance is an important challenge for clinical treatments. The main causes of radioresistance include hypoxia in the tumor microenvironment, the antioxidant system within cancer cells, and the upregulation of DNA repair proteins. Here, a multiple radiosensitization strategy of high-Z-element-based radiation enhancement is designed, attenuating hypoxia and microRNA therapy. The novel 2D graphdiyne (GDY) can firmly anchor and disperse CeO2 nanoparticles to form GDY-CeO2 nanocomposites, which exhibit superior catalase-mimic activity in decomposing H2O2 to O-2 to significantly alleviate tumor hypoxia, promote radiation-induced DNA damage, and ultimately inhibit tumor growth in vivo. The miR181a-2-3p (miR181a) serum levels in patients are predictive of the response to preoperative radiotherapy in locally advanced esophageal squamous cell carcinoma (ESCC) and facilitate personalized treatment. Moreover, miR181a can act as a radiosensitizer by directly targeting RAD17 and regulating the Chk2 pathway. Subsequently, the GDY-CeO2 nanocomposites with miR181a are conjugated with the iRGD-grafted polyoxyethylene glycol (short for nano-miR181a), which can increase the stability, efficiently deliver miR181a to tumor, and exhibit low toxicity. Notably, nano-miR181a can overcome radioresistance and enhance therapeutic efficacy both in a subcutaneous tumor model and human-patient-derived xenograft models. Overall, this GDY-CeO2 nanozyme and miR181a-based multisensitized radiotherapy strategy provides a promising therapeutic approach for ESCC.
推荐引用方式
GB/T 7714：

Zhou Xuantong,You Min,Wang Fuhui, et al. Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer [J].ADVANCED MATERIALS,2021,33(24).
APA：

Zhou Xuantong,You Min,Wang Fuhui,Wang Zhenzhen,&Chen Chunying.(2021).Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer .ADVANCED MATERIALS,33(24).
MLA：

Zhou Xuantong, et al. "Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer" .ADVANCED MATERIALS 33,24(2021).
入库时间：

5/16/2021 10:19:40 PM
更新时间：

5/16/2021 10:19:40 PM
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