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Ribosome Proteins Represented by RPL27A Mark the Development and Metastasis of Triple-Negative Breast Cancer in Mouse and Human 期刊论文

编号：

14F3DADDFAEEEF07404C89D68FA3C6F6
作者：

Zhao, Weipeng(赵伟鹏)#*^[1]Li, Xichuan^[2];Nian, Weiqi^[3];Wang, Jun^[4];Wang, Xiaorui^[1];Sun, Linlin^[1];Zhu, Ye^[1];Tong, Zhongsheng(佟仲生)*^[1]
语种：

英文
期刊：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY ISSN：2296-634X 2021 年 9 卷 ; AUG 23
收录：
关键词：

single cell RNA-sequencing triple negative breast cancer ribosomal protein RPL27A EIF2 signaling
摘要：

Triple-negative breast cancer (TNBC) is known to have a poor prognosis and limited treatment options. The lack of targeted therapies and poor prognosis of patients with TNBC have made it urgent to discover novel critical diagnosis and therapeutic targets in the TNBC field. Here, in the current study, we integrated the single-cell RNA-sequencing (scRNA-seq) data from four normal mouse mammary tissues and four mouse breast tumors. Comparative analysis was conducted to identify the gene profiles of normal epithelial cells and cancer cells at different models. Surprisingly, two ribosomal protein genes, Rpl27a and Rpl15, were significantly upregulated in the cancer cells in all the TNBC models. Next, we accessed the scRNA-seq data from human primary and metastatic TNBC tissues, and comparative analysis revealed gene profiles of human primary and metastatic TNBC cancer cells. Ribosomal protein genes, represented by RPL27A and RPL15, showed significantly upregulated expression in metastatic TNBC cancer cells. Pathway analysis on the upregulated genes of the metastatic TNBC cancer cells identified the key regulators and signaling pathways that were driving the metastasis of the TNBC cancer cells. Specifically, EIF2 signaling was significantly activated, and major member genes of this signaling pathway were upregulated. In vitro study revealed that targeting RPL27A or EIF2 signaling in a TNBC cell line, MDA-MB-231, significantly reduced cell migration and invasion. Altogether, these data suggested that the RPL27A gene is conducting critical functions in TNBC cancer development and metastasis and is a potential therapeutic target for TNBC.
推荐引用方式
GB/T 7714：

Zhao Weipeng,Li Xichuan,Nian Weiqi, et al. Ribosome Proteins Represented by RPL27A Mark the Development and Metastasis of Triple-Negative Breast Cancer in Mouse and Human [J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2021,9.
APA：

Zhao Weipeng,Li Xichuan,Nian Weiqi,Wang Jun,&Tong Zhongsheng.(2021).Ribosome Proteins Represented by RPL27A Mark the Development and Metastasis of Triple-Negative Breast Cancer in Mouse and Human .FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9.
MLA：

Zhao Weipeng, et al. "Ribosome Proteins Represented by RPL27A Mark the Development and Metastasis of Triple-Negative Breast Cancer in Mouse and Human" .FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021).
入库时间：

8/2/2021 12:00:00 AM
更新时间：

8/2/2021 12:00:00 AM
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