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The histone demethylase KDM4A promotes esophageal cancer progression by epigenetically activating LRG1-mediated TGF-β signaling 期刊论文

编号：

296A03D4E84FB8A39A1F7E442D5F42AC
作者：

Han, Yueting(韩月婷)#^[1]Wang, Huiya(王慧雅)#^[1]Guo, Yaoyang(郭耀阳)#^[1]Zhang, Hongdian(张洪典)#^[1]Wen, Xinyi#^[1]Zhang, Miao^[1];Gao, Zhanhua^[1];Hao, Jie^[1];Qiu, Minghan^[1];Ren, Li(任丽)*^[1]Hu, Dongzhi(胡冬至)*^[1]Ba, Yi*^[2]Sun, Bei(孙蓓)*^[1,3]Zhang, Haiyang(张海洋)*^[1]
语种：

英文
期刊：

APOPTOSIS ISSN：1360-8185 2026 年 31 卷 3 期 ; MAR 11
收录：
关键词：

KDM4A LRG1 ESCC TGF-beta signaling Epigenetics
摘要：

Esophageal squamous cell carcinoma (ESCC) remains a lethal malignancy with a poor 5-year survival rate of approximately 20%, necessitating the identification of novel therapeutic targets. Here, we show that KDM4A is significantly upregulated in esophageal squamous cell carcinoma (ESCC) and its high expression correlates with poor prognosis. Functional assays demonstrated that KDM4A promotes ESCC cell proliferation, migration, invasion, and tumor growth in vitro and in vivo. Mechanistically, KDM4A demethylates H3K9me3 at the LRG1 promoter, thereby enhancing LRG1 transcription and activating the TGF-beta pathway to drive epithelial-mesenchymal transition (EMT) and cancer stemness. Knockdown of KDM4A or LRG1 suppresses these oncogenic phenotypes, while LRG1 overexpression rescues KDM4A deficiency-induced impairments. Clinically, KDM4A and LRG1 are co-overexpressed in ESCC tissues and associated with advanced tumor stage and shorter overall survival. These findings identify the KDM4A-LRG1-TGF-beta axis as a critical driver of ESCC progression and a potential therapeutic target.
推荐引用方式
GB/T 7714：

Han Yueting,Wang Huiya,Guo Yaoyang, et al. The histone demethylase KDM4A promotes esophageal cancer progression by epigenetically activating LRG1-mediated TGF-β signaling [J].APOPTOSIS,2026,31(3).
APA：

Han Yueting,Wang Huiya,Guo Yaoyang,Zhang Hongdian,&Zhang Haiyang.(2026).The histone demethylase KDM4A promotes esophageal cancer progression by epigenetically activating LRG1-mediated TGF-β signaling .APOPTOSIS,31(3).
MLA：

Han Yueting, et al. "The histone demethylase KDM4A promotes esophageal cancer progression by epigenetically activating LRG1-mediated TGF-β signaling" .APOPTOSIS 31,3(2026).
入库时间：

3/26/2026 9:26:42 PM
更新时间：

3/26/2026 9:26:42 PM

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