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WT1-interacting protein inhibits cell proliferation and tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis 期刊论文

编号：

4ed805b5-509d-4733-b022-48e65a3aba46
作者：

Wu, Zhiqiang(吴志强)#^[1]Qiu, Minghan^[1,2];Mi, Zeyun(米泽云)#^[3]Meng, Maobin(孟茂斌)^[1]Guo, Yu^[4];Jiang, Xiangli(蒋湘俐)^[5]Fang, Jiaping^[6];Wang, Hui^[1];Zhao, Jinlin^[1];Liu, Zhuang^[1];Qian, Dong(钱东)^[1]Yuan, Zhiyong(袁智勇)*^[1]
语种：

英文
期刊：

MOLECULAR ONCOLOGY ISSN：1574-7891 2019 年 13 卷 5 期 (1059 - 1074) ; MAY
收录：
关键词：

AKT cell proliferation FOXO1 non-small cell lung cancer NSCLC WTIP
摘要：

Lung cancer is the most common cancer and the leading cause of cancer-related death worldwide; hence, it is imperative that the mechanisms underlying the malignant properties of lung cancer be uncovered in order to efficiently treat this disease. Increasing evidence has shown that WT1interacting protein (WTIP) plays important roles both physiologically and pathologically in humans; however, the role of WTIP in cancer is unknown. Here, we investigated the role and mechanism of WTIP in cell proliferation and tumorigenesis of non-small-cell lung cancer (NSCLC). We report that WTIP is a tumor suppressor in human NSCLC. We found that WTIP expression was significantly reduced in both NSCLC cell lines and clinical specimens compared to that in normal controls; this reduction was largely attributed to promoter hypermethylation. Downregulation of WTIP significantly correlates with poor prognosis and predicts a shorter overall survival and progression-free survival among NSCLC patients. Moreover, ectopic overexpression of WTIP dramatically inhibits cell proliferation and tumorigenesis in vitro and in vivo; conversely, depletion of WTIP expression shows the opposite effects. Mechanistically, WTIP impairs AKT phosphorylation and activation, leading to enhanced expression and transcriptional activity of FOXO1, which further increases p21Cip1 and p27Kip1, and decreases cyclin D1, which consequently results in cell cycle arrest. Collectively, the results of the current study indicate that WTIP is an important proliferation-related gene and that WTIP expression may represent a novel prognostic biomarker for NSCLC.
推荐引用方式
GB/T 7714：

Wu Zhiqiang,Qiu Minghan,Mi Zeyun, et al. WT1-interacting protein inhibits cell proliferation and tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis [J].MOLECULAR ONCOLOGY,2019,13(5):1059-1074.
APA：

Wu Zhiqiang,Qiu Minghan,Mi Zeyun,Meng Maobin,&Yuan Zhiyong.(2019).WT1-interacting protein inhibits cell proliferation and tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis .MOLECULAR ONCOLOGY,13(5):1059-1074.
MLA：

Wu Zhiqiang, et al. "WT1-interacting protein inhibits cell proliferation and tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis" .MOLECULAR ONCOLOGY 13,5(2019):1059-1074.
入库时间：

2/7/2020 6:14:50 PM
更新时间：

2/7/2020 6:14:50 PM
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