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Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)  期刊论文  

  • 编号：
    72E16CAD07968D54DDB6BF43A3165B4A
  • 作者：
    Wang, Zheng#[1]Sun, Huichuan(孙惠川)#[1]Zhou, Jian*[1]Xie, Qing[2];Bi, Xinyu[3];Liu, Xiufeng[4];Liu, Rong[5];Zhao, Ming[6];Bai, Xueli[7];Ji, Yuan[8];Xu, Li[9];Jia, Weidong[10];Zeng, Shaochong[11];Li, Gong[12];Zhang, Wei(张伟)[13,14]Shen, Shunli[15];Rao, Shengxiang[16];Shi, Guoming[1];Zhang, Lan[17];Zhu, Xiaodong(朱小东)[1]Wu, Zhifeng[11];Wang, Jiabei[18];Tang, Haowen[19];Bai, Dousheng[20];Chen, Yajin[21];Chen, Yongjun[22];Dai, Chaoliu[23];Gu, Fangming[24];Guo, Jinhe[25];Guo, Rongping[26];Guo, Wenzhi[27];Han, Feng[28];Han, Guohong[29];Hao, Chunyi[30];Huang, Tao[31];Huang, Xiaolun[32,33];Huang, Yangqing[34];Huang, Zhiyong[35];Jiao, Shunchang[36];Li, Deyu[37];Li, Tao[38];Li, Xiangcheng[39];Li, Guangming[40];Liang, Ping[41];Liang, Xiao[42];Lin, Jinguan[43];Liu, Fubao[44];Liu, Jiwei[45];Liu, Jingfeng[46,47];Lu, Zheng[48];Lv, Weifu[49];Mao, Yilei[50];Meng, Zhiqiang[51];Peng, Chuang[52];Peng, Li[53];Peng, Tao[54];Shi, Ming[9];Shi, Yinghong[1,55];Song, Tianqiang(宋天强)[13,14]Tan, Guang[56];Tang, Yunqiang[57];Tao, Kaishan[58];Wan, Chidan[59];Wang, Guangyi[60];Wang, Kui[24];Wang, Lu[61];Wang, Maoqiang[62];Wang, Shunxiang[63];Wang, Wentao[64];Wen, Tianfu[65,66];Xiang, Bangde[67];Xing, Baocai[68];Xu, Jianming[36];Xu, Jun[69,70];Yan, Sheng[71];Yang, Dinghua[72];Yang, Jiayin[64];Yin, Guowen[73];Yu, Zhengping[74];Zeng, Yongyi[75];Zhang, Jialin[76];Zhang, Shuijun[77];Zhang, Ti(张倜)[78]Zhang, Yamin(张雅敏)[79]Zhang, Yu[80];Zhang, Yubao[81];Zhang, Zhiwei[35];Zhang, Aibin[82];Zhao, Haitao(赵海涛)[83]Zhao, Hong[84];Zhou, Ledu[85];Zhou, Weiping[24];Zhu, Zhenyu[86];Qin, Shukui[87];Shen, Feng[88];Cai, Xiujun[89];Cai, Jianqiang[3];Chen, Minshan[9];Li, Qiang(李强)[90]Liu, Lianxin[91];Wang, Weilin[92];Liang, Tingbo[7];Zhang, Bixiang[35];Lu, Shichun[19];Cheng, Shuqun[24];Ren, Zhenggang[17];Wu, Hong[64];Kuang, Ming[15];Teng, Gaojun[25];Dou, Kefeng[93];Dong, Jiahong[94];Chen, Xiaoping[35];Wang, Xuehao[95];Zheng, Shusen[96];Fan, Jia*[1]
  • 语种：
    英文
  • 期刊：
    HEPATOBILIARY SURGERY AND NUTRITION ISSN：2304-3881 2026 年 15 卷 3 期 ; JUN
  • 收录：
     
  • 关键词：
    Liver neoplasms conversion therapy perioperative therapy consensus China
  • 摘要：

    Background: A significant portion of primary liver cancer patients in China are diagnosed at intermediate-to-advanced stages, often making them ineligible for curative surgery. Furthermore, high postoperative recurrence rates, reaching up to 70%, pose a major challenge for long-term survival. The emergence of novel systemic treatments, such as immune checkpoint inhibitor combinations, and advancements in locoregional therapies have created new opportunities for conversion and perioperative strategies. This updated consensus aims to standardize the clinical application of these therapies based on the latest evidence, with the objective of improving patient prognosis. Methods: A multidisciplinary committee of 97 experts was convened to revise previous guidelines. The process involved a comprehensive search of medical databases and conference proceedings, with evidence graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Consensus statements were finalized through a formal electronic voting process, requiring at least 80% agreement for approval, resulting in 18 updated statements. Results: The consensus provides refined definitions for conversion and perioperative therapy. It recommends various strategies for oncological conversion, including systemic therapy with anti-angiogenic drugs plus immunotherapy, and locoregional approaches like precision transarterial chemoembolization (TACE) and hepatic artery infusion chemotherapy (HAIC). The document strongly affirms surgical resection as a crucial step for achieving long-term survival after successful conversion and offers guidance on surgical timing and adjuvant therapy. For resectable patients with high-risk features, neoadjuvant and adjuvant treatments are outlined to mitigate recurrence. The consensus also advocates for using dynamic enhanced magnetic resonance imaging ( MRI) and the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria for efficacy assessment and underscores the essential role of a multidisciplinary team in management. Conclusions: This updated consensus offers standardized, evidence-based guidance for clinicians on implementing conversion and perioperative strategies to optimize patient-centered care and highlights the need for continued research to further refine these promising approaches.

  • 推荐引用方式
    GB/T 7714：
    Wang Zheng,Sun Huichuan,Zhou Jian, et al. Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition) [J].HEPATOBILIARY SURGERY AND NUTRITION,2026,15(3).
  • APA：
    Wang Zheng,Sun Huichuan,Zhou Jian,Xie Qing,&Fan Jia.(2026).Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition) .HEPATOBILIARY SURGERY AND NUTRITION,15(3).
  • MLA：
    Wang Zheng, et al. "Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)" .HEPATOBILIARY SURGERY AND NUTRITION 15,3(2026).
  • 入库时间：
    7/16/2026 9:37:51 PM
  • 更新时间：
    7/16/2026 9:37:51 PM
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