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Tumor control probability modeling of stereotactic radiosurgery and fractionated stereotactic radiosurgery for patients with brainstem metastases 期刊论文

编号：

7BF15AC41487E55A59EA69A4F670713E
作者：

Xu, JiWen#^[1,2]Wang, HuanHuan(王欢欢)#^[1,2]Li, XinTian#^[1,2]Yan, YuanYuan^[1,2];Xu, XinMing^[1,2,3];Zeng, HongYu^[1,2];Chen, Qing^[1,2];Yu, XinRu^[4];He, Yuan^[1,2];Zheng, BoYu^[1,2];Bai, Hui^[1,2];Peng, YuChen^[1,2];Wang, WenQi^[1,2];Niu, ZhiMin(牛志敏)^[1,2]Shi, JinMing^[1,2];Zaorsky, Nicholas G.^[5];Wang, XiaoGuang(王晓光)^[6]Yuan, ZhiYong(袁智勇)^[1,2]Meng, MaoBin(孟茂斌)*^[1,2]
语种：

英文
期刊：

RADIOTHERAPY AND ONCOLOGY ISSN：0167-8140 2026 年 218 卷 ; MAY
收录：
关键词：

Brainstem metastases Stereotactic radiosurgery Fractionated stereotactic radiosurgery Tumor control probability Local control Overall survival Adverse events
摘要：

Purpose: Evidence supports stereotactic radiosurgery (SRS) or fractionated stereotactic radiosurgery (fSRS) for brainstem metastases (BSMs). The optimal dose-fractionation schedule remains undefined. We evaluated tumor control probability (TCP), overall survival (OS), and treatment-related adverse events after SRS and fSRS. Methods and materials: We conducted a comprehensive review of studies from the PubMed, Embase, and Cochrane databases and from our institutional cohort. Logistic dose-response models compared TCP and OS using biological effective dose (BED) calculated using the linear-quadratic model and equivalent doses for 1-5 fractions. The alpha/(i ratio was estimated by fitting TCP data using maximum likelihood estimation across three representative radiobiological models. Results: A total of 2,237 patients (2,423 lesions) from 28 articles and our institutional cohort were included in the analysis. The median tumor volume was 0.4 cm3 (range, 0.04-4.2; interquartile range [IQR], 0.19-0.995), and the median follow-up duration was 10 months (range, 3.2-37.7; IQR, 5.8-14.15). Fitting the clinical TCP data from SRS and fSRS consistently yielded alpha/(i ratios of approximately 20 Gy across all three radiobiological models. SRS and fSRS achieved an estimated 1-year TCP of 90% at a BED20 ti 36.8 Gy (ti 18.9 Gy/1 fx, 23.3 Gy/2 fx, 25.7 Gy/3 fx, 27.4 Gy/4 fx, and 28.6 Gy/5 fx) and a 2-year TCP of 90% at a BED20 ti 41.4 Gy (ti 20.5 Gy/1 fx, 25.3 Gy/2 fx, 28.2 Gy/3 fx, 30.1 Gy/4 fx, and 31.5 Gy/5 fx). Estimated 1- and 2-year TCPs of 80%, 85%, and 90% were achieved with single-fraction doses of 15.8, 17.2, and 18.9 Gy as well as 17.4, 18.8, and 20.5 Gy, respectively. A trend toward significance was observed for BED20 and equivalent dose in relation to 1- and 2-year OS following SRS and fSRS. Grade >= 3 adverse events were infrequent (3.1%), with only one patient experiencing grade 5 hemorrhage (0.04%).
推荐引用方式
GB/T 7714：

Xu Ji-Wen,Wang Huan-Huan,Li Xin-Tian, et al. Tumor control probability modeling of stereotactic radiosurgery and fractionated stereotactic radiosurgery for patients with brainstem metastases [J].RADIOTHERAPY AND ONCOLOGY,2026,218.
APA：

Xu Ji-Wen,Wang Huan-Huan,Li Xin-Tian,Yan Yuan-Yuan,&Meng Mao-Bin.(2026).Tumor control probability modeling of stereotactic radiosurgery and fractionated stereotactic radiosurgery for patients with brainstem metastases .RADIOTHERAPY AND ONCOLOGY,218.
MLA：

Xu Ji-Wen, et al. "Tumor control probability modeling of stereotactic radiosurgery and fractionated stereotactic radiosurgery for patients with brainstem metastases" .RADIOTHERAPY AND ONCOLOGY 218(2026).
入库时间：

4/9/2026 9:43:49 PM
更新时间：

4/9/2026 9:43:49 PM

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