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Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era 期刊论文

编号：

C9B7232E39F66091ACAD8AA3CD371697
作者：

Wang, Zhan#^[1]Li, Luwei#^[2,3]Yang, Shuai#^[1]Li, Zhengrui#^[4]Zhang, Pengpeng^[5];Shi, Run^[6];Zhou, Xing^[7];Tang, Xiaojuan*^[8]Li, Qi*^[7]
语种：

英文
期刊：

FRONTIERS IN MICROBIOLOGY ISSN：1664-302X 2024 年 15 卷 ; OCT 8
收录：
关键词：

COVID-19 myocardial fibrosis TGF-beta 1 RAAS mechanisms
摘要：

Since December 2019, coronavirus disease 2019 (COVID-19) has been spreading worldwide with devastating immediate or long-term effects on people''s health. Although the lungs are the primary organ affected by COVID-19, individuals infected with SARS-CoV-2 also develop systemic lesions involving multiple organs throughout the body, such as the cardiovascular system. Emerging evidence reveals that COVID-19 could generate myocardial fibrosis, termed "COVID-19-associated myocardial fibrosis." It can result from the activation of fibroblasts via the renin-angiotensin-aldosterone system (RAAS), transforming growth factor-beta 1 (TGF-beta 1), microRNAs, and other pathways, and can also occur in other cellular interactions with SARS-CoV-2, such as immunocytes, endothelial cells. Nonetheless, to gain a more profound insight into the natural progression of COVID-19-related myocardial fibrosis, additional investigations are necessary. This review delves into the underlying mechanisms contributing to COVID-19-associated myocardial fibrosis while also examining the antifibrotic potential of current COVID-19 treatments, thereby offering guidance for future clinical trials of these medications. Ultimately, we propose future research directions for COVID-19-associated myocardial fibrosis in the post-COVID-19 era, such as artificial intelligence (AI) telemedicine. We also recommend that relevant tests be added to the follow-up of COVID-19 patients to detect myocardial fibrosis promptly.
推荐引用方式
GB/T 7714：

Wang Zhan,Li Luwei,Yang Shuai, et al. Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era [J].FRONTIERS IN MICROBIOLOGY,2024,15.
APA：

Wang Zhan,Li Luwei,Yang Shuai,Li Zhengrui,&Li Qi.(2024).Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era .FRONTIERS IN MICROBIOLOGY,15.
MLA：

Wang Zhan, et al. "Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era" .FRONTIERS IN MICROBIOLOGY 15(2024).
入库时间：

11/3/2024 9:23:31 PM
更新时间：

11/10/2024 9:42:12 PM
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