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POD24-Based prognostic signature enables personalized risk stratification in mantle cell lymphoma 期刊论文

编号：

EDD4E6E013858C354ACE80A598F65103
作者：

He, Yizi#^[1]Wang, Caiqin#^[1]Pan, Tao^[3];Cai, Qingqing^[4];Zhou, Dehui^[5];Zhang, Huilai^[6];Liang, Rong^[7];Zeng, Dongfeng^[8];Ye, Haige^[9];Liang, Yun^[10];Sun, Xiuhua^[11];Xiao, Ling*^[2]Zhou, Hui*^[1]
语种：

英文
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2025 年 15 卷 1 期 ; MAR 13 2025
收录：
关键词：

Mantle cell lymphoma Progression of disease within 24 months Prognostic Clinical factor
摘要：

Mantle cell lymphoma (MCL) exhibits significant biological and clinical heterogeneity, necessitating a refined prognostic model. According to the drawbacks of existing models which do not truly define the complexity of the disease, we used the clinical and molecular data from nine medical centers of China to validate the predictive utility of progression of disease within 24 months (POD24), and also established a novel prognostic risk model to predict the survival outcome of MCL patients. POD24 occurred in 37.7% of evaluable patients, with the median over survival being 21 months (vs. 122 months for those without POD24, P < 0.0001). The POD24-based risk model had the highest sensitivity to predict survival with the most satisfying AUC value for risk score (AUC = 0.869). In conclusion, we confirm the obviously predictive performance of POD24 and established a novel risk model combined POD24 and clinical factors. Our new prognostic model might be helpful in effectively classify MCL patients with high-risk groups in terms of survival rate, which may help in selecting high-risk MCL patients for more intensive treatment at time of relapse.
推荐引用方式
GB/T 7714：

He Yizi,Wang Caiqin,Pan Tao, et al. POD24-Based prognostic signature enables personalized risk stratification in mantle cell lymphoma [J].SCIENTIFIC REPORTS,2025,15(1).
APA：

He Yizi,Wang Caiqin,Pan Tao,Cai Qingqing,&Zhou Hui.(2025).POD24-Based prognostic signature enables personalized risk stratification in mantle cell lymphoma .SCIENTIFIC REPORTS,15(1).
MLA：

He Yizi, et al. "POD24-Based prognostic signature enables personalized risk stratification in mantle cell lymphoma" .SCIENTIFIC REPORTS 15,1(2025).
入库时间：

8/19/2026 10:00:35 AM
更新时间：

8/23/2026 11:27:15 PM

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